Week of 26 October – 1 November 2026¶
What is the risk of intracranial hemorrhage (ICH) at birth in newborns with hemophilia?¶
Answer:
Thirteen studies encompassing 5845 live-born neonates with hemophilia were included. A total of 131 neonatal ICH events were identified. The pooled cumulative incidence of neonatal ICH was 2.10% (95% CI: 1.4–2.79), with substantial between-study heterogeneity. Fatal ICH was rare, with a pooled mortality estimate of approximately 0.2% (95% CI 0.0–1.2).
— Risk of intracranial hemorrhage in neonates with hemophilia: a systematic review and meta-analysis (BMC Pediatrics 2026)
Source: Risk of intracranial hemorrhage in neonates with hemophilia: a systematic review and meta-analysis